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Lappaol F

CAS No. 69394-17-8

Lappaol F( —— )

Catalog No. M31751 CAS No. 69394-17-8

1. Lappaol F has antioxidant and antiaging properties, it may promote the C. elegans longevity and stress resistance through a JNK-1-DAF-16 cascade.

1. Lappaol F has antioxidant and antiaging properties, it may promote the C. elegans longevity and stress resistance through a JNK-1-DAF-16 cascade.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    Lappaol F
  • Note
    Research use only, not for human use.
  • Brief Description
    1. Lappaol F has antioxidant and antiaging properties, it may promote the C. elegans longevity and stress resistance through a JNK-1-DAF-16 cascade.
  • Description
    Lappaol F has antioxidant and antiaging properties, it may promote the C. elegans longevity and stress resistance through a JNK-1-DAF-16 cascade. Lappaol F has potential chemosensitizing activity, it may be candidates for developing novel adjuvant anticancer agents. Lappaol F exhibits antitumor activity in vitro and in vivo and has strong potential to be developed as an anticancer therapeutic.Lappaol F strongly inhibited NO production in the LPS-stimulated RAW264.7 cells with the IC(50) value of 9.5 microM.
  • In Vitro
    Immunofluorescence Cell Line:HeLa cells Concentration:50 μM Incubation Time:48 h Result:Decreased the nuclear accumulation of YAP.Western Blot Analysis Cell Line:HeLa、MDA-MB-231、MCF-7 cells Concentration:50 μM Incubation Time:24, 48, 72 h Result:Increased level of p21 and p27, and reduced level of CDK2, cyclin B1, and CDK1.RT-PCR Cell Line:HeLa, MDA-MB-231, SW480 and PC3 cells Concentration:50 μM Incubation Time:12/24/36 h Result:Lowered transcriptional levels of YAP and its target genes (such as BIRC5, GLI2, c-Myc, Bcl-2, Axin2 and AREG).
  • In Vivo
    Animal Model:Human colon cancer (SW480) xenografts in nude miceDosage:10 and 20 mg/kg/d Administration:i.v., 15 days Result:Inhibited tumor size by 48% (10 mg/kg/d) and 55% (20 mg/kg/d) without affecting the body weight.Induced apoptosis in tumor tissues. Up-regulated the levels of 14-3-3σin tumor tissues and down-regulated the levels of YAP.
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    ——
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    69394-17-8
  • Formula Weight
    714.8
  • Molecular Formula
    C40H42O12
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    ——
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

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